Projects

SCANDAT project

Most of my research the last few years has been centered on the long-term effects of blood donation and transfusion. This research has been based on the Swedish-Danish Scandinavian Donations and Transfusions Database (SCANDAT), which effectively covers all the computerized blood transfusion data in Sweden and Denmark since the late 1960′s. We’ve especially focused on cancer as the outcome, with several important publications in high impact journals, but have also investigated risks of death, etc. Most recently, my focus has shifted somewhat towards more acute effects of blood transfusions from a clinical perspective. Since the original version of the SCANDAT database was limited to data until 2002 and was permanently de-identified, we’ve recently completed the massive undertaking of recreating the database with data until 2012. More information is coming about this.

I currently have specific funding for a range of studies based on the SCANDAT-database:

  • Risk of fractures in frequent, long-term apheresis donors (support from NIH): here we study whether the exposure to citrate during apheresis procedures, which transiently chelates calcium, may have an effect on fracture risk in very frequent, long-term apheresis donors.
  • Clustering of ARDS to specific blood donors (support from Swedish research council and Swedish heart-lung foundation): here we are investigating an observation that blood from a small fraction of all blood donors seem to lead to an increased risk of ARDS (presumably TRALI) in recipients of their blood.
  • Search for ”new” transfusion transmitted diseases (from NIH): here we are mining the great wealth of the SCANDAT database in an agnostic search for risk correlations between the risk of a wide range of diseases in blood donors and their recipients.
Cancer epidemiology

I have a number of ongoing studies of cancer epidemiology:

  • Sex-differences in the site-specific survival of cancer (together with Profs Mats Lambe and Paul Dickman)
  • Long-term survival of patients with acute lymphatic leukemia in Sweden, the US and UK (together with Profs Paul Dickman and Magnus Björkholm)
  • Etc.